140 research outputs found
TRIDENT: an infrared camera optimized for the detection of methanated substellar companions around nearby stars
A near-infrared (0.85-2.5 microns) camera in use at the Canada-France-Hawaii
Telescope and at the 1.6m telescope of the Observatoire du Mont-Megantic is
described. The camera is based on a Hawaii-1 1024x1024 HgCdTe array detector.
Its main feature is to acquire three simultaneous images at three wavelengths
(simultaneous differential imaging) across the methane absorption bandhead at
1.6 micron, enabling an accurate subtraction of the stellar point spread
function (PSF) and the detection of faint close methanated companions. The
instrument has no coronagraph and features a fast (1 MHz) data acquisition
system without reset anomaly, yielding high observing efficiencies on bright
stars. The performance of the instrument is described, and it is illustrated by
CFHT images of the nearby star Ups And. TRIDENT can detect (3 sigma) a
methanated companion with DeltaH=10 at 0.5 arcsec from the star in one hour of
observing time. Non-common path aberrations between the three optical paths are
the limiting factors preventing further PSF attenuation. Reference star
subtraction and instrument rotation improve the detection limit by one order of
magnitude.Comment: 8 pages, 6 figures, to appear in SPIE 486
TRIDENT: an Infrared Differential Imaging Camera Optimized for the Detection of Methanated Substellar Companions
A near-infrared camera in use at the Canada-France-Hawaii Telescope (CFHT)
and at the 1.6-m telescope of the Observatoire du Mont-Megantic is described.
The camera is based on a Hawaii-1 1024x1024 HgCdTe array detector. Its main
feature is to acquire three simultaneous images at three wavelengths across the
methane absorption bandhead at 1.6 microns, enabling, in theory, an accurate
subtraction of the stellar point spread function (PSF) and the detection of
faint close methanated companions. The instrument has no coronagraph and
features fast data acquisition, yielding high observing efficiency on bright
stars. The performance of the instrument is described, and it is illustrated by
laboratory tests and CFHT observations of the nearby stars GL526, Ups And and
Chi And. TRIDENT can detect (6 sigma) a methanated companion with delta H = 9.5
at 0.5" separation from the star in one hour of observing time. Non-common path
aberrations and amplitude modulation differences between the three optical
paths are likely to be the limiting factors preventing further PSF attenuation.
Instrument rotation and reference star subtraction improve the detection limit
by a factor of 2 and 4 respectively. A PSF noise attenuation model is presented
to estimate the non-common path wavefront difference effect on PSF subtraction
performance.Comment: 41 pages, 16 figures, accepted for publication in PAS
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Knockdown of Ant2 Reduces Adipocyte Hypoxia And Improves Insulin Resistance in Obesity.
Decreased adipose tissue oxygen tension and increased HIF-1α expression can trigger adipose tissue inflammation and dysfunction in obesity. Our current understanding of obesity-associated decreased adipose tissue oxygen tension is mainly focused on changes in oxygen supply and angiogenesis. Here, we demonstrate that increased adipocyte O2 demand, mediated by ANT2 activity, is the dominant cause of adipocyte hypoxia. Deletion of adipocyte Ant2 improves obesity-induced intracellular adipocyte hypoxia by decreasing obesity-induced adipocyte oxygen demand, without effects on mitochondrial number or mass, or oligomycin-sensitive respiration. This led to decreased adipose tissue HIF-1α expression and inflammation with improved glucose tolerance and insulin resistance in both a preventative or therapeutic setting. Our results suggest that ANT2 may be a target for the development of insulin sensitizing drugs and that ANT2 inhibition might have clinical utility
Endometrial stromal sarcoma: a population-based analysis
To determine independent prognostic factors for the survival of patients with endometrial stromal sarcoma (ESS), data were abstracted from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute from 1988 to 2003. Kaplan–Meier and Cox proportional hazards models were used for analyses. Of 831 women diagnosed with ESS, the median age was 52 years (range: 17–96 years). In total, 59.9% had stage I, 5.1% stage II, 14.9% stage III, and 20.1% had stage IV disease. Overall, 13.0, 36.1, and 34.7% presented with grades 1, 2, and 3, respectively. Patients with stage I–II vs III–IV disease had 5 years DSS of 89.3% vs 50.3% (P<0.001) and those with grades 1, 2, and 3 cancers had survivals of 91.4, 95.4, and 42.1% (P<0.001). In multivariate analysis, older patients, black race, advanced stage, higher grade, lack of primary surgery, and nodal metastasis were independent prognostic factors for poorer survival. In younger women (<50 years) with stage I–II disease, ovarian-sparing procedures did not adversely impact survival (91.9 vs 96.2%; P=0.1). Age, race, primary surgery, stage, and grade are important prognostic factors for ESS. Excellent survival in patients with grade 1 and 2 disease of all stages supports the concept that these tumors are significantly different from grade 3 tumors. Ovarian-sparing surgeries may be considered in younger patients with early-stage disease
Malignant germ cell tumours of childhood: new associations of genomic imbalance
Malignant germ cell tumours (MGCTs) of childhood are a rare group of neoplasms that comprise many histological subtypes and arise at numerous different sites. Genomic imbalances have been described in these tumours but, largely because of the paucity of cases reported in the literature, it is unclear how they relate to abnormalities in adult MGCTs and impact on potential systems for classifying GCTs. We have used metaphase-based comparative genomic hybridisation to analyse the largest series of paediatric MGCTs reported to date, representing 34 primary tumours (22 yolk sac tumours (YSTs), 11 germinomatous tumours and one metastatic embryonal carcinoma) occurring in children from birth to age 16, including 17 ovarian MGCTs. The large dataset enabled us to undertake statistical analysis, with the aim of identifying associations worthy of further investigation between patterns of genomic imbalance and clinicopathological parameters. The YSTs showed an increased frequency of 1p- (P=0.003), 3p+ (P=0.02), 4q− (P=0.07) and 6q− (P=0.004) compared to germinomatous tumours. Gain of 12p, which is invariably seen in adult MGCTs, was present in 53% of primary MGCTs of children aged 5–16 and was also observed in four of 14 YSTs affecting children less than 5. Two of these cases (14% of MGCTs in children less than 5) showed gain of the 12p11 locus considered to be particularly relevant in adult MGCTs. Gain of 12p showed a significant association with gain of 12q. Conversely, MGCTs without 12p gain displayed a significantly increased frequency of loss on 16p (P=0.04), suggesting that this imbalance may contribute to tumour development in such cases. This data provides new insight into the biology of this under-investigated tumour group and will direct future studies on the significance of specific genetic abnormalities
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